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MED28 Antibody, HRP conjugated

Datasheet
Code CSB-PA863955LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) MED28 Polyclonal antibody
Uniprot No.
Q9H204
Target Names
MED28
Alternative Names
EG1 antibody; Endothelial-derived protein 1 antibody; FKSG20 antibody; Magicin antibody; med28 antibody; MED28_HUMAN antibody; Mediator complex subunit 28 antibody; Mediator of RNA polymerase II transcription subunit 28 antibody; Merlin and Grb2-interacting cytoskeletal protein antibody; Tumor angiogenesis marker EG-1 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Mediator of RNA polymerase II transcription subunit 28 protein (1-178AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
ELISA Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May be part of a complex containing NF2/merlin that participates in cellular signaling to the actin cytoskeleton downstream of tyrosine kinase signaling pathways.
Gene References into Functions
  1. MED28 modulates the development of epithelial-mesenchymal transition through NFkappaB in human breast cancer cells. PMID: 27662245
  2. All trans-retinoic acid can reverse the suppressive effect of MED28 on HBP1 and E-cadherin and inactivate the Wnt/beta-catenin pathway in colorectal cancer, suggesting a protective effect of ATRA against colorectal cancer. PMID: 26660958
  3. This paper describes a link between Med23 and IFN-lambda3, provides evidence for the crucial role of IFN-lambda in HSV-1 immune control. PMID: 23950709
  4. These data indicate that MED28 regulates cellular migration in a MEK1-dependent manner in human breast cancer cells, reinforcing the important cellular roles of MED28. PMID: 22495818
  5. High MED28 is associated with breast cancer. PMID: 20584319
  6. demonstrate an interaction between Grb2 and magicin. In addition, merlin is capable of forming a ternary complex with magicin and Grb2 PMID: 15467741
  7. EG-1 is a positive stimulator of cellular proliferation, and may possibly be involved in signaling pathways involving Src and MAPK activation. PMID: 16024617
  8. May serve as a multi-faceted adaptor/scaffold to relay cellular signaling to the cytoskeleton and from the cytoskeleton to the nucleus. PMID: 16899217
  9. EG-1 may be involved in signaling pathways including c-Src activation. PMID: 16964398
  10. EG-1 has a role in breast tumor growth PMID: 17568184
  11. Study reports that down-regulation of human Med28 expression in NIH3T3 cells results in a significant induction of several genes associated with smooth muscle cell (SMC)differentiation; conversely, overexpression of MED28 represses SMC gene expression. PMID: 17848560

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Subcellular Location
Nucleus. Cytoplasm. Membrane; Peripheral membrane protein. Note=According to PubMed:15467741, it is cytoplasmic and mainly membrane-associated.
Protein Families
Mediator complex subunit 28 family
Tissue Specificity
Widely expressed. Highly expressed in vascular tissues such as placenta, testis and liver.
Database Links

HGNC: 24628

OMIM: 610311

KEGG: hsa:80306

STRING: 9606.ENSP00000237380

UniGene: Hs.731966

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